Personal Data gone from user profile

So one of my clients computers is not seeing personal data in any user profile on the machine. Here is everything relevant.

Windows 7

Domain User

Local profiles (although logging in through domain)

No new hardware (originally thought maybe there was a HDD swap)

user data gone from 2 different domain profiles

NOT defaulting to temp profile (checked in registry)

If I didn't know better, I'd say there was never anything done with these profiles on this computer.

Any ideas????? Me and all the rest of the techs here are stumped.

via Bleeping Computer Last 20 Posts http://www.bleepingcomputer.com/forums/t/510461/personal-data-gone-from-user-profile/