Win32:Malware-gen

First post from a novice, guys. I have Windows Vista and Avast Antivirus but noticed pop-ups, computer and keys freezes. Ran avast several times but keeps Win 32: Malware-gen reappearing. Additionally, another Win 32, is unremoveable. Look forward to any suggestions for removal. Thanks!

via Bleeping Computer Last 20 Posts http://www.bleepingcomputer.com/forums/t/509173/win32malware-gen/